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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MED1 All Species: 14.24
Human Site: T687 Identified Species: 28.48
UniProt: Q15648 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15648 NP_004765.2 1581 168478 T687 I C S G S N K T K K K K S S R
Chimpanzee Pan troglodytes XP_001172395 1581 168474 T687 I C S G S N K T K K K K S S R
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_537654 1583 168625 T687 I C P G S N K T K K K K S S R
Cat Felis silvestris
Mouse Mus musculus Q925J9 1575 167122 A687 M C S G S N K A K K K K S S R
Rat Rattus norvegicus NP_001127833 1567 166392 T672 M C S G S N K T K K N K S S R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521297 422 46589
Chicken Gallus gallus XP_418125 1594 169410 K698 E M G P G G S K Q K K K K S R
Frog Xenopus laevis Q6INP8 1570 165663 K667 L G A S A T G K P K K K R P R
Zebra Danio Brachydanio rerio XP_700209 1694 176982 Q715 G M S M K Q S Q Q Q V V D M T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VP05 1475 149513 L613 A I A G L I N L K R E T D P Q
Honey Bee Apis mellifera XP_395879 1811 193227 T830 T T L P S S I T I T P I P A P
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786427 2421 258175 D946 I P T G S E F D V Q H R T T T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.9 N.A. 98 N.A. 94.4 93.9 N.A. 24.4 87.6 72.5 56.4 N.A. 22 24.4 N.A. 25.7
Protein Similarity: 100 100 N.A. 98.9 N.A. 97.1 96.5 N.A. 25.7 93.5 81.7 69 N.A. 38.9 41.1 N.A. 38.5
P-Site Identity: 100 100 N.A. 93.3 N.A. 86.6 86.6 N.A. 0 33.3 26.6 6.6 N.A. 13.3 13.3 N.A. 20
P-Site Similarity: 100 100 N.A. 93.3 N.A. 93.3 93.3 N.A. 0 40 46.6 20 N.A. 40 26.6 N.A. 53.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 17 0 9 0 0 9 0 0 0 0 0 9 0 % A
% Cys: 0 42 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 9 0 0 0 0 17 0 0 % D
% Glu: 9 0 0 0 0 9 0 0 0 0 9 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % F
% Gly: 9 9 9 59 9 9 9 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % H
% Ile: 34 9 0 0 0 9 9 0 9 0 0 9 0 0 0 % I
% Lys: 0 0 0 0 9 0 42 17 50 59 50 59 9 0 0 % K
% Leu: 9 0 9 0 9 0 0 9 0 0 0 0 0 0 0 % L
% Met: 17 17 0 9 0 0 0 0 0 0 0 0 0 9 0 % M
% Asn: 0 0 0 0 0 42 9 0 0 0 9 0 0 0 0 % N
% Pro: 0 9 9 17 0 0 0 0 9 0 9 0 9 17 9 % P
% Gln: 0 0 0 0 0 9 0 9 17 17 0 0 0 0 9 % Q
% Arg: 0 0 0 0 0 0 0 0 0 9 0 9 9 0 59 % R
% Ser: 0 0 42 9 59 9 17 0 0 0 0 0 42 50 0 % S
% Thr: 9 9 9 0 0 9 0 42 0 9 0 9 9 9 17 % T
% Val: 0 0 0 0 0 0 0 0 9 0 9 9 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _